Since March to September in 1996, we used Xuezhikang to cure 50
cases of NIDDM, and the effects were evident. Report is as follows.
this trial, 50 cases of diabetes mellitus (DM) are compatible with
the diagnosis standard of DM, which provided by the DM Specialist
Committee of WHO, in type belonging to NIDDM.
In order to exclude hyperlipidemia caused by blood sugar increased,
through control blood sugar (blood sugar on an empty stomach is
less than 6.7mmol/L and 2-hr postprandial is less than 8.9mmol/L)
three months later, recheck blood lipid, that fitted one or more
criteria as follows: (1)TC=5.98mmol/L;(2)TG=22.2mmol/L; (3) HDL-C
male=1.04mmol/L, female =1.16mmol/L,(4)LDL-C=3.36mmol/L, and cases
in the last half a year had suffered from myocardial infarction,
cerebral vascular strock, severe trauma, major surgery, nephrotic
syndrome, hypothyroidism, acute or chronic hepatobiliary disorders,
gout, homozygote familial hypercholesterolemia and drug induced
hyperlipidemia. 50 patients were all selected from DM special outpatient
clinic and on admission, 21 are male and 29 female, age is from
40 to 72 years old and average 60 years old. 37 patients complicate
with hypertension and 8 coronary heart disease (CHD). 14 cases are
obese (body weight index =24). 28 TC, 22 TG and 42 LDL-C increased
respectively, 26 HDL-C is below the lower limit of normal range.
50 patients were asked to keep the habit of living
and diet as before, and maintained the drugs in curing diabetes
mellitus, hypertension and coronary heart disease identical with
that before treatment. Adopted the Xuezhikang capsule, production
of the WBL Peking University Biotech Co.,Ltd. (Batch number 951107),
which possesses major composition of hydroxy-methyl-glutaryl coenzyme
A (HMG-COA)reductase inhibitors and multiple kinds of unsaturated
fatty acids and amino acids that human body needs. Each tablet contains
0.3g, take orally 0.6g each time, twice a day for 4 weeks. Before
and after the treatment measure and record BP, cardiac rhythm and
heart rate, ECG, blood lipid, BUN, creatinine, SGPT, creatine phosphokinase
and routine of blood and urine. Statistical processing with t test
for auto-comparison before and after the treatment.
Standard of Determination of Curative Effect: According to "The
Guidance Principle of the Clinic Study on the Cardiovascular Drug"
adopted by the Ministry of Health in 1988. The result indicated
that the total efficiency , in lowering TC,TG, TCHDLC / HDL-C and
increasing HDL-C, is 26 (92.95),19 (86.4%),45 (90%) and 15 (57.7%)
respectively. After the treatment the average of TC, TG, LDL-C,
TC-HDL-C/HDL-C are decreased and HDL-c increased by 25.7%, 48.4%,
33.0%, 32.0% and 21.4% respectively,there are significant difference
compared with that before the treatment(P<0.01-0.001).
used in this experiment, is produced and refined from red yeast
rice of TCM. Through the animal experiments confirmed that it can
significantly reduces the level of blood lipid, and also can inhibit
the formation of atherosclerotic plaque and the deposition of lipid
in the liver in hyperlipidemia rabbit. The clinical observation
of this trial further confirmed that lipid-adjusting effect of Xuezhikang
is evident. In addition, through competitive inhibition for HMG-CoA,
which reduces TC synthesis and its level in serum, and through feedback
adjustment, to increased activity of LDL receptor on cell surface,
and accelerate the elimination LDL, at same time significantly reduces
TG and increased HDL-C. The differential diagnosis of TCM recognized
that the occurrence of hyperlipidemia is concerned with the factor
of spleen-asthenia, phlegm damp, dyspepsia, blood stasis and etc.
Red yeast rice is sweet taste and warm in nature, and Ben Cao Gang
Mu noted that it can "promoting digestion and blood flow, invigorating
the spleen for eliminating dampness". It is thus clear that
Xuezhikang through strengthening spleen and stomach, invigorating,
promote digestion and removing blood stasis, to improve transport
of body fluid, achieve adjusting metabolism disorder of blood lipid
in vivo. Thus, Xuezhikang capsule is a kind of curing hyperlipidemia
medicine of TCM, effective and easy to be tolerated. Because of
the benefit are appeared quicker and definite, without side effects,
Xuezhikang is worthwhile to spread its clinical application.